Chasa has good advice and info.

Huffyuv is for editing not playback. If Premiere plays it fine, then don't worry about the video players not being able to keep up.

Since, I suppose, you're remastering your vid, try to only take what you need to conserve disk space. Don't bother encoding the sound part if you won't use it. Also, it's easier on the system to have the clip files on a disk other than the system disk. Less clogging through the bus system.